Rabbit Secondary Antibodies
ABclonal Technology PXDN Rabbit mAb
This gene encodes a heme-containing peroxidase that is secreted into the extracellular matrix It is involved in extracellular matrix formation and may function in the physiological and pathological fibrogenic response in fibrotic kidney Mutations in this gene cause corneal opacification and other ocular anomalies and also microphthalmia and anterior segment dysgenesis
ABclonal Technology PE Rabbit anti-Mouse CD28 mAb
Enables protein kinase binding activity Acts upstream of or within several processes including positive regulation of immune response positive regulation of intracellular signal transduction and regulation of lymphocyte activation Located in external side of plasma membrane and immunological synapse Human ortholog(s) of this gene implicated in multiple sclerosis and type 1 diabetes mellitus Orthologous to human CD28 (CD28 molecule)
ABclonal Technology APC Rabbit anti-Mouse CD47 mAb
Predicted to enable protein binding activity involved in heterotypic cell-cell adhesion and thrombospondin receptor activity Involved in regulation of nitric oxide biosynthetic process Acts upstream of or within several processes including monocyte aggregation opsonization and positive regulation of phagocytosis Located in extracellular exosome Is integral component of plasma membrane Is expressed in several structures including alimentary system central nervous system genitourinary system hemolymphoid system gland and liver and biliary system Orthologous to human CD47 (CD47 molecule)
ABclonal Technology 700 Rabbit anti-Human EGFR
The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily This protein is a receptor for members of the epidermal growth factor family EGFR is a cell surface protein that binds to epidermal growth factor thus inducing receptor dimerization and tyrosine autophosphorylation leading to cell proliferation Mutations in this gene are associated with lung cancer EGFR is a component of the cytokine storm which contributes to a severe form of Coronavirus Disease 2019 (COVID-19) resulting from infection with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)
ABclonal Technology 488 Rabbit anti-Human AGTR2
This gene encodes a G-protein coupled receptor 1 family member serving as a receptor for angiotensin II It is an integral membrane protein highly expressed in fetuses and neonates but less so in adults except in the brain adrenal medulla and atretic ovary This receptor mediates programmed cell death playing a role in developmental biology and disease pathophysiology Mutations are linked to X-linked cognitive disability SARS-CoV and SARS-CoV-2 infections downregulate ACE2 receptors triggering inflammatory lesions particularly in the lungs The angiotensin AT2 receptor is upregulated in bronchoalveolar lavage samples from COVID-19 patients suggesting its role in inflammation
ABclonal Technology MAP3K4 Rabbit mAb
This gene encodes MEKK4 (also known as MTK1) a MAPK kinase kinase (MAPKKK) that activates stress-responsive MAPK pathways MAPK cascades consist of three kinases a MAPKKK activates a MAPKK which then activates a MAPK MEKK4 specifically activates the CSBP2 (p38) and JNK pathways but not the ERK pathway It contains a kinase domain at the C-terminus and a potential regulatory domain at the N-terminus MEKK4 is activated by environmental stresses such as UV radiation osmotic shock and inflammatory signals In vitro MEKK4 phosphorylates and activates PRKMK6 and SERK1 MAPKKs for CSBP2 and JNK respectively but not PRKMK1 which activates ERKs MEKK4 is a key mediator of CSBP2 activation and a minor contributor to JNK signaling Multiple alternatively spliced isoforms of MEKK4 have been identified
ABclonal Technology SMG1 Rabbit mAb
This gene encodes a protein involved in nonsense-mediated mRNA decay (NMD) as part of the mRNA surveillance complex The protein has kinase activity and is thought to function in NMD by phosphorylating the regulator of nonsense transcripts 1 protein Alternatively spliced transcript variants have been described but their full-length nature has yet to be determined
ABclonal Technology 647 Rabbit anti-Human TrkA
This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family This kinase is a membrane-bound receptor that upon neurotrophin binding phosphorylates itself and members of the MAPK pathway The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes Mutations in this gene have been associated with congenital insensitivity to pain anhidrosis self-mutilating behavior mental retardation and cancer Alternate transcriptional splice variants of this gene have been found but only three have been characterized to date
ABclonal Technology 647 Rabbit anti-Human TrkA
This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family This kinase is a membrane-bound receptor that upon neurotrophin binding phosphorylates itself and members of the MAPK pathway The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes Mutations in this gene have been associated with congenital insensitivity to pain anhidrosis self-mutilating behavior mental retardation and cancer Alternate transcriptional splice variants of this gene have been found but only three have been characterized to date
ABclonal Technology PE Rabbit anti-Mouse CD200/OX2
Predicted to enable protein binding activity involved in heterotypic cell-cell adhesion Involved in negative regulation of cell population proliferation negative regulation of macrophage activation and negative regulation of neuroinflammatory response Located in cell surface Is expressed in several structures including anterior naris aorta bone nervous system and retina Used to study autoimmune disease Orthologous to human CD200 (CD200 molecule)
ABclonal Technology 488 Rabbit anti-Human MERTK
This gene is a member of the MER AXL TYRO3 receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains two Ig-like C2-type (immunoglobulin-like) domains and one tyrosine kinase domain Mutations in this gene have been associated with disruption of the retinal pigment epithelium (RPE) phagocytosis pathway and onset of autosomal recessive retinitis pigmentosa (RP)
ABclonal Technology 450 Rabbit anti-Human BCL6
The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain This protein acts as a sequence-specific repressor of transcription and has been shown to modulate the transcription of STAT-dependent IL-4 responses of B cells This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL) and may be involved in the pathogenesis of DLCL Alternatively spliced transcript variants encoding different protein isoforms have been found for this gene
ABclonal Technology PE Rabbit anti-Mouse CD200/OX2
Predicted to enable protein binding activity involved in heterotypic cell-cell adhesion Involved in negative regulation of cell population proliferation negative regulation of macrophage activation and negative regulation of neuroinflammatory response Located in cell surface Is expressed in several structures including anterior naris aorta bone nervous system and retina Used to study autoimmune disease Orthologous to human CD200 (CD200 molecule)
ABclonal Technology PE Rabbit anti-Human CD33 mAb
Enables protein phosphatase binding activity and sialic acid binding activity Involved in several processes including negative regulation of cytokine production negative regulation of monocyte activation and positive regulation of protein tyrosine phosphatase activity Located in several cellular components including Golgi apparatus external side of plasma membrane and peroxisome